Head: Maria Jolanta Rędowicz

Degrees:

2010 Professor of Biological Sciences, nomination by the President of the Republic of Poland, Nencki Institute of Experimental Biology, PAS

2002 DSc Habil, Nencki Institute of Experimental Biology, PAS

1991 PhD in Biology, Nencki Institute of Experimental Biology, PAS

1984 MSc in Pharmacy (Diploma cum laude), Medical University of Warsaw

Research trainings:

1999 Laboratory of Cell Biology, NHLBI, NIH, Bethesda, USA

1992-1998 Laboratory of Cell Biology, NHLBI, NIH, Bethesda, USA

1987, 1988 Institute of Molecular Biology, Austrian Academy of Sciences, Salzburg, Austria

1985 Eötvös Loránd University, Budapest, Hungary

Professional employments:

2011-present Professor, Nencki Institute of Experimental Biology, PAS

2005-present Head of the Laboratory of Molecular Basis of Cell Motility, Nencki Institute of Experimental Biology, PAS

2011-2015 Head of the Department of Biochemistry, Nencki Institute of Experimental Biology, PAS

2003-2007 Head of the Department of Muscle Biochemistry, Nencki Institute of Experimental Biology, PAS

2003-2011 Associate Professor, Nencki Institute of Experimental Biology, PAS

1998-2003 Adjunct, Nencki Institute of Experimental Biology, PAS

1984-1991 Research Assistant, Nencki Institute of Experimental Biology, PAS

Honors and fellowships:

2014 Diplôme d'Honneur, Nencki Institute of Experimental Biology, PAS

2008 Team Award of the Polish and Russian Academies of Sciences for scientific collaboration

1989, 2005 Team awards, Biological Division of Polish Academy of Sciences

Staff: Magdalena Bandyszewska (PhD student), Solomiia Boyko (PhD student), Vira Chumak, Olena Karatsai (PhD student), Damian Matyśniak (PhD student), Hanna Nieznańska, Krzysztof Nieznański, Jolanta Nowak, Paweł Pomorski, Dariusz Stępkowski, Małgorzata Suszek (PhD student), Emilia Wojtera, Zbigniew Zieliński

Research profile:

• unconventional myosins and actin-binding proteins in cell migration and intracellular trafficking: studies on normal and transformed mammalian cells
• muscle plasticity and muscle pathology
• effects of arginine deprivation on cell migration and invasiveness
• calcium signaling
• multiple signaling pathways of selected nucleotide receptors
• role of prion protein in Alzheimer disease and other tauopathies
• the mechanism of cytotoxicity of the cytosolic form of prion protein.

Current research activities:

• involvement of unconventional myosins (in particular of class VI) in cell migration and intracellular trafficking of organelles and nuclear functions
• analysis of interaction of myosin VI with its tissue-specific partners
• understanding mechanisms of limb girdle muscle dystrophy (LGMD): analysis of LGMD patients' muscle biopsies
• probing arginine analogs as a component of a potential arginine deprivation-based anti-cancer therapeutical strategy
• non-calcium signaling from P2X7 nucleotide receptor
• crosstalk between calcium and small Rho GTPases signaling in glioma cells
• prion protein in therapy of Alzheimer disease
• the role of prion protein in amyloidogenesis and neurotoxicity of Tau protein
• the consequences of the interaction of cytosolic form of prion protein with microtubular cytoskeleton.

Selected publications:

Sobczak M., Chumak V., Pomorski P., Wojtera E., Majewski L., Nowak J., Yamauchi J., Rędowicz M.J. (2016) Interaction of myosin VI and its binding partner DOCK7 plays an important role in NGF-stimulated protrusion formation in PC12 cells. Biochim Biophys Acta-Mol Cell Res, 1863: 1589-1600.

Karolczak J., Pavlyk I., Majewski Ł., Sobczak M., Niewiadomski P., Rzhepetskyy., Sikorska A., Nowak N., Pomorski P., Prószyński T., Ehler E., Rędowicz M.J. (2015) Involvement of unconventional myosin VI in myoblast function and myotube formation. Histochem Cell Biol, 144: 21-38.

Pavlyk I., Rzhepetskyy Y., Jagielski A.K., Drozak J., Wasik A., Pereverzieva G., Olchowik M., Kunz-Schughart L.A., Stasyk O., Rędowicz M.J. (2015) Arginine deprivation affects glioblastoma cell adhesion, invasiveness and actin cytoskeleton organization by impairment of β-actin arginylation. Amino Acids, 47: 199-212.

Zajkowski T., Nieznańska H., Nieznański K. (2015) Stabilization of microtubular cytoskeleton protects neurons from toxicity of N-terminal fragment of cytosolic prion protein. Biochim Biophys Acta-Mol Cell Res, 1853: 2228-2239.

Nieznański K., Surewicz K., Chen S,. Nieznańska H., Surewicz W.K. (2014) Interaction between prion protein and Aβ amyloid fibrils revisited. ACS Chem Neurosci, 5: 340-345.